After years and years of research, researchers at the University of Washington have finally made a groundbreaking discovery about the sequencing of proteins. And all because of a video game, which makes sense for many considering all types of college in Washington have to deal with that awful weather.
Researchers were hoping to find a drug that could block retroviral proteases, an enzyme involved in the maturation of HIV. Nothing had yet yielded results, because their computer had not yet generated a viable model of what a retroviral protease molecule would look like. So Dr. Firas Khatib of the Department of Biochemistry hoped that humans would succeed where computers had failed. But where could the department turn to get a wider variety of opinions and strategies for enzyme sequencing?
Foldit was the solution. This website hosted a game, the goal of which is to fold a protein as close as possible, hide sidechains, and keep the proteins from touching each other. Gamers scored points based on their ability to keep proteins compact and apart, and hydrophobic sidechains buried.